Anti-Rituximab (Mabthera®) (Human) ELISA Kit

Product Overview

A sandwich ELISA kit for the quantitative measurement of Anti-Rituximab (Mabthera®) in Human serum and plasma.

Rituximab (Mabthera®) is a genetically engineered chimeric murine/human monoclonal antibody specific to CD20. CD20 is an approximately 35 KDa transmembrane phosphoprotein involved in the activation, proliferation, and differentiation of B-lymphocytes. It is absent in terminally differentiated plasma cells. The Fab domain of rituximab binds to the CD20 antigen on B-lymphocytes and the Fc domain recruits immune effector functions to induce apoptosis in B cells. It is used in treating leukemias and lymphomas, some autoimmune disorders, and organ transplant. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. 96Trace’s BioSimTM anti-Rituximab ELISA kit is designed to quantify/measure the antibody against Rituximab with high specificity and sensitivity in biological matrices.

Assay Information

Performance Data

Applications

This ELISA kit is used for quantitative measurement of Anti-Rituximab (Mabthera®) in Human serum and plasma.

Features & Benefits

• Designed for quantitative measurement of Anti-Rituximab (Mabthera®).
• Assay format: Sandwich ELISA.
• Sample type: Human serum and plasma.
• Detection method: Absorbance (450 nm).
• Detection Range: 62 - 500 ng/ml
• Sensitivity: 30 ng/ml
• Kit size: 96 Well.

Storage & Shipping

Product Details