Anti-Pembrolizumab (Keytruda®) (Human) ELISA Kit

Product Overview

A sandwich ELISA kit for the qualitative detection of Anti-Pembrolizumab (Keytruda®) in Human serum and plasma.

Pembrolizumab (Keytruda®) is an antibody drug that targets the cell surface receptor programmed cell death protein 1 (PD-1) found on T cells. By preventing the binding of its ligands (PD-L1 and PD-L2), pembrolizumab induces an antitumor immune response. Upregulation of PD-1 ligands is a mechanism for tumors to evade antitumor immune response; when PD-1 binds its ligand, the T cell receives an inhibitory signal leading to T cell anergy and blockade of anti-tumour immune response. Instead of directly targeting tumor tissue to induce tumor cell death, pembrolizumab acts as a checkpoint inhibitor to stimulate immune responses to eliminate cancer cells. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. 96Trace’s BioSimTM anti-Pembrolizumab ELISA kit is designed to detect antibody against Pembrolizumab with high specificity and sensitivity in biological matrices.

Assay Information

Applications

This ELISA kit is used for qualitative detection of Anti-Pembrolizumab (Keytruda®) in Human serum and plasma.

Features & Benefits

• Designed for qualitative detection of Anti-Pembrolizumab (Keytruda®).
• Assay format: Sandwich ELISA.
• Sample type: Human serum and plasma.
• Detection method: Absorbance (450 nm).
• Kit size: 96 Well.

Storage & Shipping

Product Details